Microglia: dismantling and rebuilding circuits after acute neurological injury

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Microglia in Neuronal Circuits

1 Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854, USA 2Children’s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA 3Department of Neurobiology, Zhejiang University School of Medicine, 866 Yu Hang Tang Road, Hangzhou, Zhejiang 310058, China 4Department of Psychiatry, University of British Columbia, 2211 Wesbrook Mall, Vanc...

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Traumatic brain injury (TBI) is a public health problem worldwide. Secondary damage of brain injury begins within a few minutes after the trauma and can last a long time. It can be reversible, unlike primary injury. Therefore, therapeutic intervention can be used. The aims of this study were to assess the effects of minocycline on neurological function and serum S100B protein and neuron-specifi...

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Microglia and monocytes synergistically promote the transition from acute to chronic pain after nerve injury

Microglia and peripheral monocytes contribute to hypersensitivity in rodent models of neuropathic pain. However, the precise respective function of microglia and peripheral monocytes has not been investigated in these models. To address this question, here we combined transgenic mice and pharmacological tools to specifically and temporally control the depletion of microglia and monocytes in a m...

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Effects of minocycline on neurological outcomes in patients with acute traumatic brain injury: a pilot study

Traumatic brain injury (TBI) is a public health problem worldwide. Secondary damage of brain injury begins within a few minutes after the trauma and can last a long time. It can be reversible, unlike primary injury. Therefore, therapeutic intervention can be used. The aims of this study were to assess the effects of minocycline on neurological function and serum S100B protein and neuron-specifi...

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ژورنال

عنوان ژورنال: Metabolic Brain Disease

سال: 2014

ISSN: 0885-7490,1573-7365

DOI: 10.1007/s11011-014-9539-y